Zhang, Z., Xu, J., Drapaca, C.: Particle squeezing in narrow confinements. Ĭhen, H., Zhang, Z., Liu, H., Zhang, Z.: Hybrid magnetic and deformability based isolation of circulating tumor cells using microfluidics. Whitesides, G.M.: The origins and the future of microfluidics. Gossett, D.R., Weaver, W.M., Mach, A.J., Hur, S.C., Tse, H.T.K., Lee, W., Amini, H., Di Carlo, D.: Label-free cell separation and sorting in microfluidic systems. Zhang, Z., Chen, X., Xu, J.: Entry effects of droplet in a micro confinement: implications for deformation-based circulating tumor cell microfiltration. Zhang, Z., Xu, J., Hong, B., Chen, X.: The effects of 3D channel geometry on CTC passing pressure-towards deformability-based cancer cell separation. Zhang, X., Chen, X., Tan, H.: On the thin-film-dominated passing pressure of cancer cell squeezing through a microfluidic CTC chip. Mohamed, H., Murray, M., Turner, J.N., Caggana, M.: Isolation of tumor cells using size and deformation. 304, 987–990 (2004)ĭincau, B.M., Aghilinejad, A., Hammersley, T., Chen, X., Kim, J.-H.: Deterministic lateral displacement (DLD) in the high Reynolds number regime: high-throughput and dynamic separation characteristics. Huang, L.R., Cox, E.C., Austin, R.H., Sturm, J.C.: Continuous particle separation through deterministic lateral displacement. In: Allgayer, H., Heiss, M.M., Schildberg, F.W. Gertler, R., Rosenberg, R., Fuehrer, K., Dahm, M., Nekarda, H., Siewert, J.R.: Detection of circulating tumor cells in blood using an optimized density gradient centrifugation. Gascoyne, P.R.C., Noshari, J., Anderson, T.J., Becker, F.F.: Isolation of rare cells from cell mixtures by dielectrophoresis. Īghaamoo, M., Zhang, Z., Chen, X., Xu, J.: Deformability-based circulating tumor cell separation with conical-shaped microfilters: concept, optimization, and design criteria. ĭong, Y., Skelley, A.M., Merdek, K.D., Sprott, K.M., Jiang, C., Pierceall, W.E., Lin, J., Stocum, M., Carney, W.P., Smirnov, D.A.: Microfluidics and circulating tumor cells. Our study provides insights into the dynamics of a compound droplet squeezing through a conical-shaped microfilter and offers constructive guidance for the design and optimization of high-throughput CTC microfilters.īray, F., Ferlay, J., Soerjomataram, I., Siegel, R.L., Torre, L.A., Jemal, A.: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. Additionally, the maximum instantaneous cell velocity, shear stress and pressure all occur at the same critical stage, as the nucleus passes through the exit of the microfilter channel. Results reveal that the deformation-induced surface tension pressure of the cell nucleus is the dominant component of the critical pressure. The shear stress and critical pressure under different flow rates were investigated as well. Then, the crucial design parameters including pore angles and operating flow rates were analyzed. Pressure signature, shear stress and instantaneous cell velocity during the passing process through a conical microfilter were investigated in great detail in order to understand the fluid dynamics affecting the cell squeezing process. The immiscible interface was tracked by the volume-of-fluid method with the surface tension accounted for using the continuum surface force method. Utilizing the octree-based Adaptive-Mesh-Refinement algorithm, a CTC was modeled as a compound Newtonian droplet moving through a microfilter with non-uniform cross sections. In this study, numerical simulation was employed. To design and optimize a CTC microfilter, in-depth studies of the dynamics of a CTC squeezing through a confined constriction are necessary. Decades of research have made progress in CTC detection using deformability-based microfilters however, developing a high-throughput CTC microfilter remains a challenging task due to the lack of the essential understanding of microscopic multiphase flow. Circulating tumor cells (CTCs) are regarded as important biomarkers for early cancer detection and treatment.
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